Mitral Valve Regurgitation (MVR) occurs when blood flows backwards into the left atrium through the damaged valve after the left ventricle contracts. This may allow blood to flow in both directions during the ventricular contraction, which can lead to increased pressure within the left atrium, the pulmonary veins, and if severe enough may lead to a build-up of fluid within the lungs. This may deteriorate into signs of heart failure if left undiagnosed and untreated.1
As with many degenerative conditions, age is a common risk factor, however, the following are also risk factors:
Mitral valve regurgitation may be caused by a number of different things that can damage and/or reduce the effectiveness of the mitral valve. The condition may be further classified into causes being:
Primary MVR is referring to a physical abnormality with the valve itself:
Secondary MVR refers to conditions that may have damaged the mitral valve such as:
Many people may not present with any signs of mitral valve disease, however, when the disease is advanced symptoms might include:
If the atrium is enlarged enough, there may be a predisposition for the patient to experience irregular heart rhythms or atrial fibrillation. This can often be an early diagnostic indication of advanced mitral valve disease.5
Many patients are unaware that they have Mitral Valve Regurgitation and therefore diagnosis might be made incidentally at a routine GP follow up. The first sign may be the presence of a heart murmur, along with the signs and symptoms outlined above.
An Echocardiogram (echo) is the most common testing modality ordered from a GP with a high index of suspicion that heart disease is present. If the presence of the MVR is confirmed, it will typically be classified by its severity, which includes the following:
Additionally, other diagnostic modalities may be used to determine the presence and severity of Mitral Valve Regurgitation. For example, a chest x-ray may be used to identify if an enlarged heart is present. Transoesophageal echo (TOE) and Magnetic Resonance Imaging (MRI) may also be used to indicate the severity of MVR. An Electrocardiograph (ECG) may be performed to identify an irregular heart rhythm (also known as Atrial Fibrillation) but may not have any diagnostic value related to the severity of Mitral Valve Regurgitation.6
Treatment for mitral valve regurgitation will depend on the severity of symptoms and impact on the quality of life, taking into consideration other medical conditions as well. This may be a complex process and involve General Practitioners, Cardiologists, Heart Failure Specialists and other medical professionals to determine what is the most suitable treatment regime for any individual patient.
Patients may be prescribed medications to help alleviate the symptoms of MVR, namely signs of heart failure, and these medications may include:
In some cases, the mitral valve regurgitation is so severe that the mitral valve will need to be replaced or repaired. The decision to repair or replace the damaged valve depends on a number of factors including other pre-existing medical conditions, the age of the patient, as well as, the patients’ ability to rehabilitate after surgery. There are many similarities between aortic valve treatment and mitral valve surgical treatment options.
Types of replacement mitral valves:
There are two main types of surgical mitral valves available:
Surgery may include open-heart surgery or use minimally invasive techniques to replace or repair the damaged mitral valve. Specialist centres can also use a minimally invasive surgical approach with robot-assisted surgery.
In some cases, patients may not be suitable for an open heart procedure to replace the mitral valve and instead will be more suitable to a less invasive treatment option. This new technique involves a specific tool that aims to reduce the amount of backflow (or regurgitation) in severe mitral valve regurgitation.
It’s performed when a small catheter is inserted within the femoral artery and crosses the septal wall between the right and left atrium, allowing a prosthetic to be deployed in the failing mitral valve. The aim of this device is to bring the mitral valve leaflets closer together to ultimately reduce the amount of regurgitation, backflow that may occur, and symptoms.9