Biography

Professor Stephen Duffy is a practising Interventional and General Cardiologist at the Alfred Health where he was the Head of Cardiology General Services for 9 nine years. He is currently an Adjunct Professor, Department of Epidemiology and Preventative Medicine at the Monash University. His clinical interests include interventional cardiology, management of acute coronary syndromes and structural heart disease. Together with Tony Walton, Professor Duffy established the first transcatheter aortic valve implantation (TAVI) programme in the state of Victoria and have been treating patients with this technology for nearly nine years. They also established a transcatheter mitral valve implantation and repair programme.

Professor Duffy’s PhD and post-doctoral clinical research focused on endothelial function and oxidative stress, though his present interests include cardiac structural and coronary interventional trials, clinical outcome registries, identification and evaluation of biomarkers for unstable ischaemic heart disease, reduction of reperfusion injury following myocardial infarction, and anti-atherosclerotic effects of HDL. He supervised four PhD students to completion, with one current PhD student. He has published over 110 manuscripts, including over 100 peer-reviewed, original research publications, including many in top clinical and specialist journals. He is currently the Chief Investigator on an NHMRC Project Grant as well as on an NHRMC Centre of Research Excellence Grant.

Professor Duffy has been the Head of Cardiology General Services at Alfred Health since 2005 and is also the elected representative from Victoria on the Cardiac Society of Australia and New Zealand (CSANZ) Boar, as well as the CSANZ Victorian Division Committee. He is the Chair of the Board of the not-for-profit Australian Boys Choral Institute, was on the Interventional Cardiology Product Reference Group (HPV) for the DHS in 2009, 2011-12 and 2014-2015. He previously chaired the Alfred Health ‘Research Review Committee’ from 2003–2005 and the Alfred Health ‘Health and Social Science Ethics Committee’ from 2007–2009. He serves on Alfred Health’s ‘Clinical Outcomes Review Committee’ and is on the Steering Committee, the Clinical Quality Committee, and the Data Access, Research & Publications Committee of the Victorian Cardiac Outcomes Registry. Additionally, he was the founding member of the Melbourne Interventional Group registry and continues to serve on the Steering Committee of this registry. He was recently appointed to the Private Health Ministerial (Federal) Advisory Committee (Clinical Definitions Working Group). He served on the Australian Cardiac Procedures Registry Management Committee and was recently invited to join the Australian Cardiac Outcomes Registry Research and Publications Committee. Professor Duffy has supervised and mentored dozens of post-graduate basic and advanced trainees of the Royal Australasian College of Physicians.

He has been an Editorial Consultant to the leading international medical journal The Lancet since 2005 and is a regularly invited reviewer for numerous high-impact international journals. He has been the Australian Principal or Co-Principal investigator for numerous international first-in-human trials including AMADEUS and AVERT, and has presented more than 250 papers at both national and international meetings including the CSANZ Annual Scientific Meeting, the American Heart Association Scientific Sessions, the American College of Cardiology Scientific Sessions and the European Society of Cardiology Scientific Meeting. Professor Duffy also chaired scientific sessions internationally during the annual scientific meetings of the American Heart Association and the International Society for Heart Research. He has been an invited speaker and session chair at CSANZ Annual Scientific Meetings, ANZET meetings and the Australian National Interventional Cardiology Fellows Course.

Procedures & Conditions

Procedures Performed
  • General Cardiology
  • Transcatheter Aortic Valve Implantation (TAVI)
  • Transcatheter Mitral Valve Implantation
Conditions Treated
  • Aortic Stenosis
  • Structural Heart Disease
  • Coronary Artery Disease
  • Acute Coronary Syndromes
  • Ischaemic Heart Disease
  • Myocardial Infarction

Experience

  • Academic Fellow
    Baker Heart & Diabetes Institute 2011 - Present
  • Consultant Cardiologist
    The Alfred Hospital, Melbourne, Australia 2010 - Present
  • Head of Cardiology General Services
    The Alfred Hospital, Melbourne, Australia 2005 - 2018
  • Head of Coronary Pathophysiology Laboratory
    Baker IDI Heart & Diabetes Institute 2003 - 2015
  • Consultant Cardiologist
    The Alfred Hospital, Melbourne, Australia 2001 - Present
  • Interventional Cardiology Fellow and Research Associate
    Evans Department of Medicine, Boston University School of Medicine & Boston University Medical Centre 1999 - 2001
  • Cardiologist
    Cardiology Unit, Monash Medical Centre 1996 -1998
  • NHMRC Cardiovascular Research Scholar and Ph.D. Student
    Centre for Heart and Chest Research, Monash Medical Centre & Monash University 1995 -1998

Memberships & Awards

Professional Memberships and Affiliations
  • Royal Australian College of Physicians Fellow

  • Royal College of Physicians UK Member

  • The Cardiac Society of Australia and New Zealand Fellow

  • American Heart Association, Arteriosclerosis, Thrombosis & Vascular Biology Scientific Council Member

Awards
  • 1996

    Cardiac Society of Australia & New Zealand Annual Scientific Meeting Travelling Scholarship

  • 1996

    Cardiac Society of Australia & New Zealand Annual Scientific Meeting Poster Prize

  • 1996

    Cardiac Society of Australia & New Zealand Travelling Fellowship

  • 1997

    Cardiac Society of Australia & New Zealand “Bayer Travelling Fellowship”

  • 1997

    Southern Health Care Network “AMRAD Postgraduate Education Research Travel Grant”

  • 1997

    Cardiac Society of Australia & New Zealand Travelling Fellowship

  • 1998

    Cardiac Society of Australia & New Zealand Annual Scientific Meeting Poster Prize

  • 2000

    Cardiac Society of Australia & New Zealand Annual Scientific Meeting Travelling Scholarship

Research & Publications

Publications

1. du Peloux Menage H., Duffy, S., Yates, D.W., Hughes, J.A. Reversible sensorimotor impairment following prolonged ventilation with isoflurane and vecuronium for acute severe asthma. Thorax, 1992; 47: 1078-9.

2. New, G., Timmins, K.L., Duffy, S.J., Tran, B.T., O’Brien, R.C., Harper, R.W., Meredith, I.T.  Long-term estrogen therapy improves vascular function in male to female transsexuals. Journal of the American College of Cardiology, 1997; 29: 1437-44.

3. Duffy, S.J., Tran, B.T., New, G., Tudball, R.N., Esler, M.D., Harper, R.W., Meredith, I.T.  Continuous release of vasodilator prostanoids contributes to the regulation of resting forearm blood flow in humans. American Journal of Physiology, 1998; 274: H1174-83.

4. Duffy, S.J., New, G., Tran, B.T., Harper, R.W., Meredith, I.T. Relative contribution of vasodilator prostanoids and NO to metabolic vasodilation in the human forearm. American Journal of Physiology, 1999; 276: H663-70.

5. New, G., Duffy, S.J., Berry, K.L., Harper, R.W., Meredith, I.T. Acute administration of 17-oestradiol does not improve endothelium-dependent vasodilation in young men. Clinical Science, 1999; 97: 225-32.

6. Duffy, S.J., New, G., Harper, R.W., Meredith, I.T. Metabolic vasodilation in the human forearm is preserved in hypercholesterolemia despite impairment of endothelium-dependent and independent vasodilation.Cardiovascular Research, 1999; 43: 721-30.

7. Duffy, S.J., Castle, S.F., Harper, R.W., Meredith, I.T. Contribution of vasodilator prostanoids and nitric oxide to resting flow, metabolic vasodilation and flow-mediated dilation in human coronary circulation. Circulation, 1999; 100: 1951-7.

8. New, G., Duffy, S.J., Harper, R.W., Meredith, I.T. Estrogen improves acetylcholine-induced, but not metabolic, vasodilation in biological males. American Journal of Physiology, 1999; 277: H2341-7.

9. Duffy, S.J., Gokce, N., Holbrook, M., Huang, A., Frei, B., Keaney, J.F., Jr., Vita, J.A. Treatment of hypertension with ascorbic acid. Lancet, 1999; 354: 2048-9.

10. New, G., Duffy, S.J., Harper, R.W., Meredith, I.T. Long-term oestrogen therapy is associated with improved endothelium-dependent vasodilation in the forearm resistance circulation of biological males. Clinical and Experimental Pharmacology and Physiology, 2000; 27: 25-33.

11. Sherman, D.L., Keaney, J.F., Jr., Biegelsen, E.S., Duffy, S.J., Coffman, J.D., Vita, J.A. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension, 2000; 35: 936-41.

12. Duffy, S.J., Gokce, N., Holbrook, M., Hunter, L.M., Biegelsen, E.S., Huang, A., Keaney, J.F., Jr., Vita, J.A.  Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. American Journal of Physiology, 2001; 280: H528-34.

13. Duffy, S.J., Gelman, J.S., Peverill, R.E., Greentree, M.A., Harper, R.W., Meredith, I.T. Agreement between coronary flow velocity reserve and stress echocardiography in intermediate severity coronary stenoses. Catheterization and Cardiovascular Interventions, 2001; 53: 29-38.

14. Duffy, S.J., O’Brien, R.C., New, G., Bond, A.M., Harper, R.W., Meredith, I.T. Effect of antioxidant treatment and cholesterol lowering on resting arterial tone, metabolic vasodilation and endothelial function in the human forearm: a randomized, placebo-controlled study. Clinical and Experimental Pharmacology and Physiology, 2001; 28: 409-18.

15. Duffy, S.J., Vita, J.A., Holbrook, M., Swerdloff, P.L., Keaney, J.F., Jr. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 2001; 21: 1084-89.

16. Duffy, S.J., Biegelsen, E.S., Holbrook, M., Russell, J.D., Gokce, N., Keaney, J.F., Jr., Vita, J.A. Iron chelation improves endothelial function in patients with coronary artery disease.Circulation, 2001; 103: 2799-2804.

17. Duffy, S.J., Alison, J.F. Permanent pacemaker implantation via a persistent left superior vena cava.Clinical Cardiology, 2001; 24: 526.

18. Duffy, S.J., Keaney, J.F., Jr., Holbrook, M., Gokce, N., Swerdloff, P.L., Frei, B., Vita, J.A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation, 2001; 104: 151-6.

19. Gokce, N., Duffy, S.J., Hunter, L.M., Keaney, J.F., Jr., Vita, J.A. Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults.
American Journal of Cardiology, 2001; 88: 153-9.

20. Gokce, N., Holbrook, M., Duffy, S.J., Demissie, S., Cupples, L.A., Biegelsen, E., Keaney, J.F., Jr., Loscalzo, J., Vita, J.A. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension, 2001; 38: 1349-54.

21. Kahn, D.F., Duffy, S.J., Tomasian, D., Holbrook, M., Rescorl, L., Russell, J., Gokce, N., Loscalzo, J., Vita, J.A.  Effects of black race on forearm resistance vessel function.Hypertension, 2002; 40: 195-201.

22. Vita J.A., Gokce N., Duffy S.J., Kahn D.F., Tomasian D., Palmisano J., Thomas S., Holbrook M., Keaney J.F., Jr. Effect of atorvastatin on endothelium-dependent vasodilation in patients with coronary artery disease. American Journal of Cardiology, 2003; 91: 857-60.

23. Widlansky, M.E., Price, D.T., Gokce, N., Eberhardt, R.T., Duffy, S.J., Holbrook, M., Maxwell, C., Palmisano, J., Keaney, J.F., Jr., Morrow, J.D., Vita, J.A. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension, 2003; 42: 310-5.

24. Eberhardt, R.T., McMahon, L., Duffy, S.J., Steinberg, M.H., Perrine, S.P., Loscalzo, J., Coffman, J.D., Vita, J.A.  Sickle cell disease is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels. American Journal of Hematology, 2003; 74: 104-11.

25. Widlansky, M.E., Biegelsen, E.S., Hamburg, N.M., Duffy, S.J., Keaney, J.F., Jr., Vita, J.A. Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid.Free Radical Biology and Medicine, 2004; 36: 123-30.

26. Widlansky, M.E., Duffy, S.J., Hamburg, N.M., Gokce N., Warden, B.A., Wiseman, S., Keaney, J.F., Jr., Frei, B., Vita, J.A. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease.  Free Radical Biology and Medicine, 2005; 38: 499-506.

27. Duffy, S.J., Biegelsen, E.S., Eberhardt, R.T., Kahn, D.F., Kingwell, B.A., Vita, J.A. Low-renin hypertension with relative aldosterone excess is associated with impaired nitric oxide-mediated vasodilation. Hypertension, 2005; 46: 707-13.

28. Boak, L.M., Dart, A.M., Duffy, S.J., Chin-Dusting, J.P.F. Neither responses to exogenous nor endogenous endothelin-1 are altered in patients with hypercholesterolemia. Journal of Lipid Research, 2005; 46: 2667-72.

29. Henstridge, D.C., Kingwell, B.A., Formosa, M.F., Drew, B.G., McConell, G.K., Duffy, S.J.  Effects of the nitric oxide donor, sodium nitroprusside on resting leg glucose uptake in patients with type 2 diabetes. Diabetologia, 2005; 48: 2602-8.

30. Ajani, A.E., Szto, G., Duffy, S.J., Eccleston, D., Clark, D.J., Lefkovits, J., Chew, D.P., Warren, R., Black, A., New, G., Walton, A., Lew, R., Shaw, J., Horrigan, M., Sebastian, M., Yan, B.P., Brennan, A., Meehan, A., Reid, C., Krum, H. The foundation and launch of the Melbourne Interventional Group: A collaborative interventional cardiology project. Heart, Lung and Circulation, 2006; 15: 44-7.

More publications available upon request. 

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Presentations

  • Coronary Doppler Velocimetry: Assessment of Intermediate Severity Stenoses Monash Interventional Cardiology 2nd International Symposium on
Coronary Stenting, April 1996
  • Optimising Interventions: Doppler FloWire
Monash Interventional Cardiology 3rd International Symposium on Coronary Stenting, April 1997
  • Endothelial Control of Coronary Blood Flow 2nd Cardiovascular Registrars Research Forum Ayers Rock, Northern Territory, May 1998
  • Iron – A Novel Risk Factor for Atherosclerosis? – The Effect of Iron Chelation on Endothelial Function 
Vascular Biology Workshop in honour of Visiting Professor Richard A. Walsh, MD, Boston University Medical Center, February 2000
  • Cardiovascular Effects of Black Tea.
Victorian Heart Centre Cardiovascular Meeting, August 2001
  • Cardiovascular Protection in Hypertension – The Endothelium George Institute for Global Health, Sydney, October 2001
  • Biomarkers in Acute Coronary Syndromes
Baker Heart Research Institute 80th Birthday Symposium, October 2006
  • Stent Thrombosis in Drug-Eluting Stents
National Registrars and Fellows Interventional Meeting, 2007
  • Anti-Platelet Therapy Following PCI
Cardiac Society of Australia and New Zealand (CSANZ) Annual Scientific Meeting 2008; 
Symposium on Anti-Platelet Therapy 
Stent Thrombosis in Drug-Eluting Stents 
National Registrars and Fellows Interventional Meeting, 2009
  • PCI Complications: Stent Thrombosis 
National Registrars and Fellows Interventional Meeting, 2010
  • Stent Thrombosis – Yesterday’s News? 
Essential Percutaneous Intervention Course (EPIC), 2011
  • Interventional Nightmares 
Australia & New Zealand Endovascular Therapies (ANZET) Meeting, 2013
  • Issues in ST-Elevation Myocardial Infarction 
SAHMRI Masterclass Series, 2014
  • Peripheral Vascular Management in TAVI 
Australia & New Zealand Endovascular Therapies (ANZET) Meeting, 2016
  • Eulogy for Henry Krum 
Cardiac Society of Australia and New Zealand (CSANZ) Annual Scientific Meeting 2016; Heart Failure Council Symposium
  • TAVI Valve-in-Valve Implantation
Essential Percutaneous Intervention Course (EPIC), 2017
  • Transcatheter Mitral Valve Implantation, Essential Percutaneous Intervention Course (EPIC), 2018
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