Biography

Dr Suku Thambar is currently employed as a Senior Staff Specialist Cardiologist at Hunter New England Area Health, Newcastle, NSW, and holds a conjoint appointment as a Senior Lecturer of the Faculty of Medicine, University of Newcastle. He is based at the John Hunter Hospital, Newcastle, with a further role as a Visiting Interventional Cardiologist at the outlying Tamworth Base Hospital. Dr Thambar’s primary responsibilities are the performance of diagnostic and therapeutic percutaneous coronary interventions, management of cardiology in-patients and review of outpatients. A key component of his clinical practice is his support of clinical research in contributing to the advancement of knowledge of cardiovascular disease, and in evaluating novel patient management strategies that may lead to improved patient outcomes.

Dr Thambar’s primary clinical research interests are the use of adult stem cells in the management of acute and chronic cardiovascular diseases, and the use of catheter-based renal denervation to treat patients with resistant hypertension. Over the last decade, he has gained wide experience in clinical trials, as both Principal Investigator and Co-Investigator, and has received training for Good Clinical Practice in each trial. He has been extensively involved in Renal Denervation research at John Hunter Hospital and Newcastle Private Hospital for over 10 years. HTN-1 was the first in-human pilot study for renal denervation of which he was Principal Investigator for 1 of 5 sites worldwide. HTN-1 was followed by HTN-2 which later lead to the introduction of the Global SYMPLICITY Registry (GSR). As part of GSR, they performed 5-10 renal denervation procedures at John Hunter Hospital every year.

Dr Thambar has presented renal denervation data in both national and international forums as well as co-authoring the landmark renal denervation publication in Lancet (2009).

Procedures & Conditions

Procedures Performed
  • Diagnostic Cardiac Catheterisation (right and left sided)
  • Percutaneous Coronary Intervention
  • Intravascular Ultrasound
  • NOGA Left Ventricular Mapping
  • NOGA + DMR with Laser
  • NOGA + Intramyocardial Injection
  • Carotid: Stenting, Angiogram
  • ASD/PFO Closure
  • Cardiac Biopsy
  • Renal: Interventions, Angiogram, Denervation
  • Rotablader & Angiojet
  • Transcatheter Aortic Valve Implantation (TAVI)
  • Balloon Aortic Valvular Plasty
Conditions Treated
  • Aortic Stenosis

Experience

  • Fellowship
    Fellow of the Society of Coronary Angiography and Interventions (FSCAI) 2006
  • Senior Staff Interventional Cardiologist
    John Hunter Hospital 2000 - Current
  • Visiting Medical Officer & Conjoint Senior Lecturer
    University of Newcastle 2000 - Current
  • Interventional Cardiology Fellow
    Rhode Island Hospital, Providence, USA 1998-2000
  • Clinical Transplant Fellow
    St Vincent's Hospital 1998
  • Fellowship
    Fellow of Royal Australasian College of Physicians (FRACP) 1998

Research & Publications

Publications

1. Walters DL, Sinhal A, Baron D, Pasupati S, Thambar S*, Yong G, Jepson N, Bhindi R, Bennets J, Larbalestier R, Clarke A, Brady P, Wolfenden H, James A, El Gamel A, Jansz P. Chew DP; Initial experience with the balloon expandable Edwards-SAPIEN Transcatheter Heart Valve in Australia and New Zealand: the SOURCE ANZ Registry: Outcomes at 30 days and one year International Journal of Cardiology 1 January 2014: 170(3); 406-12.

2. Michael Haude MD, PhD, Stephen W.L. Lee MD, Stephen G. Worthley MBBS, PhD, Sigmund Silber MD, PhD, Stefan Verheye MD, PhD, Sandra Erbs MD, Mohd Ali Rosli MD, Roberto Botelho MD, PhD, Ian Meredith MBBS, PhD, Kui Hian Sim MBBS, Pieter R. Stella MD, PhD, Huay-Cheem Tan MBBS, Robert Whitbourn MBBS, Sukumaran Thambar MBBS, Alexandre Abizaid MD, PhD, Tian Hai Koh MBBS, Peter Den Heijer MD, PhD, Helen Parise ScD, Ecaterina Cristea MD, Akiko Maehara MD and Roxana Mehran MD; The REMEDEE Trial JACC: Cardiovascular Interventions 1 April 2013: 6(4); 334-343.

3. Krum H, Schlaich M, Whitbourn R, Sobotka P, Sadowski J, Bartus K, Boguslaw K, Walton A, Sievert H, Thambar S*, Abraham W, Esler M; Catheter-Based Renal Sympathetic Denervation for the Management of Resistant Hypertension Lancet 11 April 2009: 373(9671); 1275-81.

4. Hiew C, Williams T, Bhagwandeen R, Thambar S*, Mylabathula S, Bastian B, Bellamy G, Collins N; Does selective abciximab use influence clinical outcome in patients with acute STEMI undergoing primary PCI? Heart Lung & Circ 2008: 17; S167 – S 168

5. Tse HF, Thambar S*, Kwong YK, Rowlings P, Bellamy G, McCrohon J, Thomas P, Bastian B, Chan JKF, Lo G, Ho CL, Chan WS, Kwong RY, Parker JA, Hauser T, Lau CP; Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for therapeutic angiogenesis in coronary artery diseases. (PROTECT-CAD) European Heart J 2007 Dec: 28: 2998 – 3005

6. Tse HF, Thambar S*, Kwong YK, Rowlings P, Bellamy G, McCrohon J, Bastian B, Chan JKF, Lo G, Ho CL, Parker JA, Hauser T, Lau CP; Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease Am Heart J 2007 Nov: 154, Issue 5:982 e.1 – 982.e6

7. Tse HF, Thambar S*, Kwong YK, Rowlings P, Bellamy G, McCrohon J, Thomas P, Bastian B, Chan JKF, Lo G, Ho CL, Chan WS, Kwong RY, Parker JA, Hauser T, Lau CP; Safety of catheter-based intramyocardial autologous bone marrow cells Implantation for therapeutic angiogenesis Am J Cardiol 2006 Jun: 98:60-62

8. Thambar S*, Schofield L, Poppas A, Bouchard M, Williams DO, Johnson LL; Validation of R wave voltage endomyocardial mapping to assess myocardial fibrosis: comparison with thallium and dobutamine echocardiography in swine model J Interv Cardiol 2003 Feb;16(1):23-31

9. Johnson L, Thambar S*, Donahay T, Dae M, Williams DO; Effect of endomyocardial laser channels on regional innervation shown by (125) I-MIBG and autoradiography J Nucl Med 2002 Apr: 43(4):551-555

Abstracts

1. Krum H, Schlaich M, Whitbourn R, Sobotka P, Sadowski J, Bartus K, Boguslaw K, Walton A, Sievert H, Thambar S*, Abraham W, Esler M; Catheter-Based Renal Sympathetic Denervation for the Management of Resistant Hypertension Scheduled for Late-breaking Clinical Trials Presentation at the American College of Cardiology Annual Conference 28 – 31 March 2009, Miami, United States

2. Hiew C, Thambar S*, Bellamy G; Predictors of adverse outcomes in the elderly patients presented with acute ST- elevation myocardial infarction Catheterisation and Cardiovascular Interventions/Asia Pacific Interventional Advances 2006, Sydney, Australia

3. Hiew C, Diu P, Mylabathula S, Adera S, Bastian B, Thambar S*, Bhagwandeen R, Bellamy G; Primary angioplasty in acute ST-elevation myocardial infarction in the elderly (>75 years): A single centre experience Cardiac Society of Australia and New Zealand 2006 54th Annual Scientific Meeting, Canberra, Australia

4. Mylabathula S, Varghese P, Adera S, Diu P, Hiew C, Bull N, Thambar S*, Bhagwandeen R, Bastian B, Bellamy G; Ten-year follow-up of percutaneous versus surgical coronary revascularization Cardiac Society of Australia and New Zealand 2006 54th Annual Scientific Meeting, Canberra, Australia

5. Mylabathula S, Diu P, Hiew C, Adera S, Varghese P, Bull N, Bastian B, Thambar S*, Bhagwandeen R, Bellamy G; Predictors of mortality in primary PCI Cardiac Society of Australia and New Zealand 2006 54th Annual Scientific Meeting, Canberra, Australia

6. Mylabathula S, Puvaneswary P, Diu P, Hiew C, Thambar S*, Tse HF; Percutaneous intra-myocardial autologous bone marrow stem cell therapy does not cause intramyocardial calcification or neoplastic transformation in patients with chronic myocardial ischaemia Cardiac Society of Australia and New Zealand 2006 54th Annual Scientific Meeting, Canberra, Australia

7. Jayasinghe R, Diu P, Tran H, Thambar S*, Hiew C; BNP levels and contrast nephropathy in patients with impaired renal function undergoing cardiac catheterization The Royal Australia College of Physicians, Annual Scientific Meeting 2005, Wellington, New Zealand

8. Tse HF, Thambar S*, Kwong YK, Chan J, Lo G, Ho CL, Chen WH, Bellamy G, Lau CP; Long-term clinical outcome of catheter-based intramyocardial autologous bone marrow cells implantation in patients with end-stage coronary artery diseases J Am Coll Cardiol 2004 Mar: 43(5), Sup1: A39

9. Dixon R, Rizik D, Griffin J, Carrozza J, Rutherford B, Kastrati A, Thambar S*, Kuntz R, Gibbons R, Popma J, O’Neill W, The COOL -MI Investigators; A prospective, randomized trial of mild hypothermia during percutaneous intervention for acute myocardial infarction (COOL-MI): One-year clinical outcome J Am Coll Cardiol 2004 Mar: 43(5), Sup1: A251

10. Rowlings P, Thambar S*, Zaunders G, Bellamy G; Myocardial angiogenesis and myogenesis by direct injection of autologous marrow stem cells in humans Tandem BMT Meetings, Jan 2003 Keystone Colorado, USA.

11. Thambar S*, Johnson L, Schofield L, Sharaf B, Williams D; Inability of Computer-guided Endomyocardial Laser Revascularisation to Relieve Ischaemia Acutely: Observations from a Porcine Coronary Occlusion Model American Cardiology Conference, 2001 and Angiogenesis Conference, 2001

12. Thambar S*, Johnson L, Schofield L, Sharaf B, Williams D, Donahay T, Dae M; Effect of Endomyocardial Laser Channels on Regional Innervation Using I-125 MIBG and autoradiography American Cardiology Conference, 2001 and Angiogenesis conference 2001

13. Johnson L, Poppas A, Thambar S*, Schofield L, Bouchard M; A Swine Model of Chronic Multivessel Disease and LV Hibernation American Cardiology Conference, 2001 and Angiogenesis Conference 2001

14. Thambar S*, Poplin V, Johnson L, Schofield L, Sharaf B, Williams D; Assessing myocardial viability using NOGA left ventricular mapping system in a chronic ischaemic porcine model: A correlation with histology and thallium scintigraphy American Cardiology Conference, 2000

15. Thambar S*, Sharaf B, Miele N, Williams D; Assessment of global and regional wall motion by NOGA three-dimensional electromechanical mapping: A correlation with the “gold standard” contrast left ventriculogram Heart, Lung & Circ. 2000 Dec: 9(3); A164

16. Thambar S*, Poplin V, Johnson L, Schofield L, Sharaf B, Williams D; Assessing myocardial viability using NOGA left ventricular mapping system in a chronic ischaemic porcine model: A correlation with histology and thallium scintigraphy Heart, Lung & Circ. 2000 Dec: 9(3); A119

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Presentations

  • Global Experts Forum – Singapore 2018
  • Renal Denervation Program. Cardiology Department, John Hunter Hospital, Newcastle, NSW, May 2012
  • Catheter Based Renal Denervation New Frontier in the Management of Resistant Hypertension. (With Prof. R. Nanra) Abbott Pharmaceuticals Dinner Meeting, Newcastle, NSW, April 2010
  • Intramyocardial bone marrow implantation for chronic ischaemia and left ventricular dysfunction.
  • Victor Chang Research Institute 11th International Symposium in conjunction with St Vincent’s Hospital “Cardiology at the Frontier: Development, Stem Cells and Heart Failure” incorporating the 2009 Princesses’ Lecture, Sydney, Australia, 31 October 2009
  • How to establish a stem cell research program. Singapore Live 17th Annual Live Interventions in Vascular Endotherapy, National Heart Centre, Singapore, March 2008
  • Prospects For Stem Cells In Heart Disease- The Near-Term Future Cardiac Society of Australia and New Zealand 55th Annual Scientific Meeting, Wellington, New Zealand, 2007
  • Update on Hot Cell Lines, Delivery Techniques, and Current Targets Australia New Zealand Endovascular Therapies, Christchurch, New Zealand, 2007
  • First In Man Experience With Mesenchymal Precursor Cells In End-Stage IHD The New York Stem Cell Meeting, New York, United States of America, January 2007
  • Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for therapeutic angiogenesis in coronary artery disease PROTECT-CAD). EUROPCR Conference, Paris, France, 2006
  • Stem Cells for Myocardial Repair Sri Lanka Heart Association, Colombo, Sri Lanka, 2006
  • Stem Cells in Heart Disease Cardiac Society of Australia and New Zealand 54th Annual Scientific Meeting, Canberra, Australia, 2006
  • Autologous Mesenchymal Precursor Cells for Cardiac Regeneration Transcatheter Cardiovascular Therapeutics, 2006
  • Stem cells for Myocardial Angiogenesis Cardiac Society of Australia and New Zealand 52nd Annual Scientific Meeting, Brisbane, Australia, 2004
  • Stem Cells for Myocardial Angiogenesis Australian Health and Medical Research Council, 2004
  • Stem Cells for Myocardial Regeneration. World Congress of Cardiology, 2002
  • Stem Cells for Myocardial Angiogenesis. Vascular Conference, 2002
  • Stem Cells for Myocardial Angiogenesis. Address to inaugural NSW Stem Cell Network Meeting, 2002
  • Thambar S, Sharaf B, Miele N, Williams D. Assessment of global and regional wall motion by NOGA three-dimensional ectromechanical mapping: A correlation with the “gold standard” contrast left ventriculogram. Poster presentation at Brown Research Day, selected for oral presentation at AHA, 1999
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